Synthesis and biological activity of 1,2,4-oxadiazole.
Oxadiazoles have antibacterial, anti-inflammatory, anticonvulsant, anticancer, antitubercular, anti-diabetic, antihelmintic, and analgesic CNS depressant activities, among others. Due to their broad biological activity potentials, the synthesis of oxadiazole derivatives is of interest to medicinal chemists working in drug development. The presence of a halogen allows these reagents to be used.
We report the synthesis and biological assessment of 1,3,4-oxadiazole substituted 24 derivatives as novel, potential antibacterial agents. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1 H NMR, 13 C NMR, and mass spectrometry. Further these synthesized derivatives were subjected to antibacterial activity against all the selected.
Title:(1, 2, 4)-Oxadiazoles: Synthesis and Biological Applications VOLUME: 14 ISSUE: 4 Author(s):Rajesh O. Bora, Bashir Dar, Vidya Pradhan and Mazahar Farooqui Affiliation:Post Graduate and Research centre, Maulana Azad College, Aurangabad, and Indian Institute of Integrative Medicine Jammu 180001. Keywords:Anaesthetic angent, anti-inflammatory, anti-tumor agents, heterocycles, one pot.
The synthesis of 1, 3, 4-oxadiazoles is of considerable interest due to their various biological activities such as anti-bacterial 1, anti-fungal 2, antitubercular activity 3, analgesic 4, anti-inflammatory 5 and anti-convulsant activity 6. The novel oxadiazole derivatives are synthesized by cyclic condensation of hydrazine hydrate with CS 2 in the presence of alcoholic KOH to give.
N2 - A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance. AB - A new and efficient method for the synthesis of 1,3,4.
Oxadiazoles are five-membered organic heteroaromatic rings containing two nitrogens, and one oxygen atom, and they exist in different regioisomeric forms. Oxadiazoles are often used in drug synthesis with the intention of being bioisosteric replacements for ester and amide functionalities. Oxadiazole is a very weak base owing to its heteroatoms.
Academia.edu is a platform for academics to share research papers.